WebAug 9, 2024 · The cyclic GMP-AMP (cGAMP) synthase (cGAS) has been identified as a cytosolic double stranded DNA sensor that plays a pivotal role in the type I interferon and inflammation responses via the STING-dependent signaling pathway. In the past several years, a growing body of evidence has revealed that cGAS is also localized in the … WebCINS – Cargo Incident Notification System. CINS is a shipping line initiative, launched in September 2011, developed to increase safety in the supply chain, reduce the number of …
CAnCEr Targeting cancers with chromosome instability - Nature
WebChromosomal instability (CIN) in cancer cells has been reported to activate the cGAS-STING innate immunity pathway via micronuclei formation, thus affecting tumor immunity and tumor progression. However, adverse effects of the cGAS/STING pathway as they relate to CIN have not yet been investigated. … WebMay 28, 2024 · Authorised Capital ₹25.00 Lakh; Paid Up Capital ₹25.00 Lakh; Sum of Charges ₹100.00 Lakh. About. Maas Air-N-Gas Technologies Private Limited is a 1 year 7 months old Private Limited Indian Non-Government Company incorporated on 31 Aug 2024. Its registered office is in Ahmedabad, Gujarat, India. incite architects
Nuclear cGAS: sequestration and beyond Protein & Cell Oxford …
WebMar 6, 2024 · The dichotomous role of CIN-driven cell-intrinsic cGAS-STING inflammatory signalling in cancer. Activation of cGAS-STING-dependent inflammatory signalling downstream of CIN can exert both tumour ... WebFeb 1, 2024 · The proinflammatory cytokine IL6 is known to activate STAT3 signaling, and CIN induction in cancer cells increases IL6 expression. In fact, the authors find that IL6 induction requires CIN-induced cGAS/STING and downstream non-canonical NF-κB because it can be prevented by knocking out cGAS, STING, or RELB. WebIt is shown that the DNA‐PK DNA repair complex drives cGAS‐independent IRF3‐mediated type I Interferon responses and that its catalytic activity is required for cG AS‐dependent cGAMP production and optimal downstream signaling, which supports that cGas‐dependent signaling is acquired during tumorigenesis. Cytosolic DNA promotes inflammatory … incorporate alternative word